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ZO-1 Rabbit anti-Canine, Hamster, Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 21773-1-AP-20UL
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Description
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.Specifications
| ZO-1 | |
| Polyclonal | |
| Unconjugated | |
| TJP1 | |
| Tight junction protein 1, Tight junction protein ZO 1, TJP1, ZO 1, ZO1, ZO-1, Zona occludens protein 1, Zonula occludens protein 1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 100773110, 21872, 292994, 403752, 7082 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunoprecipitation, Immunofluorescence, Flow Cytometry, Western Blot | |
| 0.37 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| O97758, P39447, Q07157 | |
| TJP1 | |
| ZO-1 Fusion Protein Ag16454 | |
| 20 μL | |
| Primary | |
| Human, Canine, Hamster, Rat, Mouse | |
| Antibody | |
| IgG |
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