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NF-M Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

136.48CHF - 385.92CHF

Spécification

Antigène NF-M
Concentration 0.35 mg/mL
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunoprecipitation, Immunofluorescence
Classification Polyclonal
Conjugué Unconjugated
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
16810245
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Proteintech
20664-1-AP-20UL
20 μL
136.48CHF
20µL
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16800245
Afficher les documents
Proteintech
20664-1-AP-150UL
150 μL
385.92CHF
150µL
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En stock
 
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Description

Description

The antibody is specific to NEFM.

Neurofilaments (NFs) are a type of intermediate filament (IF) expressed almost exclusively in neuronal cells, and in those cells most prominently in large axons. NFs, in most vertebrates, are composed of three different polypeptide chains with different molecular weights - neurofilament medium protein (NF-M), high (NF-H) and light protein (NF-L), which share sequence and structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm. NF-M protein tail-mediated interactions of neurofilaments are critical for size and cytoskeletal architecture of axons, and are mediated, in part, by the highly phosphorylated tail domain of this protein. NF-M phosphorylation and O-GlcNAcylation are regulated reciprocally and affect its translocation and filament formation and function. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons and are biochemically very stable.
Spécification

Spécification

NF-M
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunoprecipitation, Immunofluorescence
Unconjugated
Rabbit
Rat, Mouse, Human
P07197, P08553, P12839
18040, 24588, 4741
Peptide
Primary
-20°C
NEFM
0.35 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
NEF3, NEFM, NF M, NFM
Nefm
IgG
Antigen Affinity Chromatography
Antibody
Vidéos
FDS
Documents

Documents

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