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FADD Monoclonal Antibody (FD19), Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen MA120168
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Beschreibung
Recommended positive controls: A431. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Spezifikation
| FADD | |
| Monoclonal | |
| 2.1 mg/mL | |
| 0.01M PBS with 15mM sodium azide; pH 7.4 | |
| Q13158 | |
| FADD | |
| Recombinant, full length, human FADD protein. | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG1 |
| ELISA, Immunoprecipitation, Western Blot | |
| FD19 | |
| Unconjugated | |
| FADD | |
| Fadd; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Mort1/FADD; protein FADD | |
| Mouse | |
| purified | |
| RUO | |
| 266610, 8772 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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